Hypnotic hazards: adverse effects of zolpidem and other z-drugs

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Hypnotic hazards: adverse effects of zolpidem and other z-drugs

Zolpidem, zopiclone and zaleplon are hypnotics with similar pharmacology to benzodiazepines. In addition to the usual adverse effects of sedative drugs, there have been unusual reactions associated with the 'z-drugs', particularly zolpidem. It is unclear why there have been so many reports of bizarre behaviour in Australians taking zolpidem. Some of the cases may be the result of other conditio...

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Paradoxical effects of the hypnotic Zolpidem in the neonatal ferret.

Hypnotic drugs designed to treat insomnia in adults are now increasingly used in children, but the effects of these compounds on neonatal sleep are poorly understood. We investigated the hypnotic effects of the commonly prescribed non-benzodiazepine sleep agent Zolpidem (Ambien) on sleep architecture and electroencephalographic (EEG) activity in the neonatal ferret. Six ferret kits were surgica...

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Evaluation of zolpidem, triazolam, and placebo as hypnotic drugs the night before surgery.

STUDY OBJECTIVE To compare the hypnotic effects of a bedtime dose of zolpidem, triazolam, and placebo. DESIGN "Double-blind, randomized, placebo- and active-controlled, parallel-group" trial. SETTING Six Canadian hospitals. PATIENTS 357 patients (aged 19 to 71 years) hospitalized the night before a surgical procedure. INTERVENTIONS At bedtime, each patient received either zolpidem 10 mg...

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Hypnotic drugs.

THIS review will treat the more commonly prescribed hypnotic agents and their sleep-inducing properties. Hypnotic agents that are seldom used (paraldehyde), drugs that are not singularly soporific but may be used either alone or as adjuncts in inducing sleep [e.g. meprobamate (Equanil, Miltown), chlordiazepoxide (Librium) and diazepam (Valium)] and drugs that have little soporific effect [antih...

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Adverse Events after Zolpidem Intake

Two case reports of adverse reactions to Zolpidem are described. In both cases, the reaction was to a dosage oflOmg occurring about 15 minutes after intake of the drug.

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ژورنال

عنوان ژورنال: Australian Prescriber

سال: 2008

ISSN: 0312-8008,1839-3942

DOI: 10.18773/austprescr.2008.084